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SYNTHETIC
PHISIOLOGY
LAB

FUNDED PROJECT

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​Synthetic Matrix Biology: Designer matrices to program healthy and diseased myocardial morphogenesis
ERC Starting grant
2020-2025, 2M Eur

UNLOOC: Unlocking the data content of Organ-on-Chips
EC Chips Joint Undertaking and Italian Ministry of Enterprises

2024-2027, 1M Eur

LigHTS: All-Optical Engineering of Human Tissue Models for Ultra High-Throughput Drug Screening
MUR FARE
2022-2027​, 400k Eur

highLight: A competence center for bio/nano-sustainability
Regione Lombardia
2021-2023, 250k Eur

Engineered in-vitro models of cardiometabolic diseases to screen RNA-based therapeutics
EU/MUR PNRR
2022-2025, 250k Eur

RESET. REsolving infections by modulating SEnescenT macrophages

MUR PRIN 2022
2023-2025, 125k Eur

MOST RECENT SPL PAPERS

HIGHLY CITED FROM THE HARVARD DAYS

An Open-Science Computational Model of Organelle Acidification to Integrate Putative Mechanisms of Synaptic Vesicle Acidification and Filling.

Baraglia EC, Fattorini G, Chattaraj S, Pasqualini F, Conti F.

Neurochem Res. 2025 Jun 5;50(3):181. doi: 10.1007/s11064-025-04432-9.

PMID: 40471464 Free PMC article.

Molecular Dynamics Simulation of Structural Assembly and Hydration of Hyaluronic Acid in Salt Aqueous Buffer.

Vasudevan S, Chattaraj S, Enrico A, Pasqualini FS.

Langmuir. 2025 Feb 18;41(6):3852-3864. doi: 10.1021/acs.langmuir.4c03966. Epub 2025 Feb 6.

PMID: 39913243 Free PMC article.

Current progress toward isogeometric modeling of the heart biophysics.

Torre M, Morganti S, Pasqualini FS, Reali A.

Biophys Rev (Melville). 2023 Nov 13;4(4):041301. doi: 10.1063/5.0152690. eCollection 2023 Dec.

PMID: 38510845 Free PMC article. Review.

When art and science collide.

Pasqualini F.

Biophys Rev (Melville). 2024 Mar 6;5(1):010401. doi: 10.1063/5.0203543. eCollection 2024 Mar.

PMID: 38505297 Free PMC article. No abstract available.

SEM2: Introducing mechanics in cell and tissue modeling using coarse-grained homogeneous particle dynamics.

Chattaraj S, Torre M, Kalcher C, Stukowski A, Morganti S, Reali A, Pasqualini FS.

APL Bioeng. 2023 Dec 5;7(4):046118. doi: 10.1063/5.0166829. eCollection 2023 Dec. PMID: 38075209 Free PMC article.

Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing

Johan U LindTravis A BusbeeAlexander D ValentineFrancesco S PasqualiniHongyan YuanMoran YadidSung-Jin ParkArda KotikianAlexander P NesmithPatrick H CampbellJoost J VlassakJennifer A LewisKevin K Parker

Nature materials 16 (3), 303-308 Paperpile PDF 907 citations | 2017

Phototactic guidance of a tissue-engineered soft-robotic ray

Sung-Jin Park, Mattia Gazzola, Kyung Soo Park, Shirley Park, Valentina Di Santo, Erin L Blevins, Johan U Lind, Patrick H Campbell, Stephanie Dauth, Andrew K Capulli, Francesco S Pasqualini, Seungkuk Ahn, Alexander Cho, Hongyan Yuan, Ben M Maoz, Ragu Vijaykumar, Jeong-Woo Choi, Karl Deisseroth, George V Lauder, L Mahadevan, Kevin Kit Parker

PMID: 27387948 PMCID: PMC552633 DOI: 10.1126/science.aaf4292

A novel computational model of the human ventricular action potential and Ca transient

Eleonora Grandi, Francesco S Pasqualini, Donald M Bers

PMID: 19835882 PMCID: PMC2813400 DOI: 10.1016/j.yjmcc.2009.09.019

A tissue-engineered scale model of the heart ventricle

Luke A MacQueen, Sean P Sheehy, Christophe O Chantre, John F Zimmerman, Francesco S Pasqualini, Xujie Liu, Josue A Goss, Patrick H Campbell, Grant M Gonzalez, Sung-Jin Park, Andrew K Capulli, John P Ferrier, T Fettah Kosar,

L Mahadevan, William T Pu, Kevin Kit Parker

PMID: 31015723 PMCID: PMC6774355 DOI: 10.1038/s41551-018-0271-5

Translational cardiac stem cell therapy: advancing from first-generation to next-generation cell types

Elena Cambria, Francesco S Pasqualini, Petra Wolint, Julia Günter,

Julia Steiger, Annina Bopp, Simon P Hoerstrup, Maximilian Y Emmert

PMID: 29302353 PMCID: PMC5677990 DOI: 10.1038/s41536-017-0024-1

JetValve: Rapid manufacturing of biohybrid scaffolds for biomimetic heart valve replacement

Andrew K Capulli, Maximillian Y Emmert, Francesco S Pasqualini, Debora Kehl, Etem Caliskan, Johan U Lind, Sean P Sheehy, Sung Jin Park, Seungkuk Ahn, Benedikt Weber, Josue A Goss, Simon P Hoerstrup, Kevin Kit Parker

​PMID: 28445803 PMCID: PMC5526340 DOI: 10.1016/j.biomaterials.2017.04.033

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© 2025 by Martina Petrelli

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