Welcome to the Synthetic Physiology Lab (SPL)

We seek to understand human physiology by re-engineering its complexity, one step at a time.

We combine computational models, human stem cells, and engineered culture platforms to create laboratory replicas of human tissues and organs


We will tackle open problems in:

  • Drug discovery

  • Disease modeling

  • Regenerative medicine

Read more about Our Culture



Dr. Pasqualini becomes a Tenured Associate Professor of Industrial Bioengineering

Given his scientific track-record and in recognition of the recently awarded European Research Council Starting Grant (ERC Stg 2019), Dr. Francesco Pasqualini was named (early tenured) associate professors in Industrial Bioengineering by the Italian Ministry of Education, University and Research (MIUR).

Prof. Pasqualini will join the (bio-)mechanics section of the Department of Civil Engineering and Architecture at the University of Pavia, in Northern Italy. He will teach subjects in the Bachelor and Master programs of Biomedical Engineering with a focus in applications of cell mechanics and tissue engineering in modern pharmacology.

Dr. Pasqualini receives an ERC Starting Grant to develop Synthetic Matrix Biology

Dr. Francesco Pasqualini received 2M eur in funding from the European Research Council (ERC) to study the role of the extracellular matrix (ECM) in cardiac development and disease.

The project is entitled "Synthetic Matrix Biology (SYNBIO.ECM): Designer matrices to program healthy and diseased myocardial morphogenesis" and seeks to develop novel computational and experimental approaches to recapitulate the early phases of human heart development in the laboratory.

We are hiring for this project, so please reach out if you are interest.


Life at the Synthetic Physiology Laboratory


Computational and Experimental Bioengineering.


We are hiring!


Publications, patents, code.


Contact Us

Synthetic Physiology Lab,
Department of Civil Engineering and Architecture,

University of Pavia,
Via Adolfo Ferrata, 3, 27100 Pavia, PV

tel: +390382985458

©2020 by Synthetic Physiology Lab.