FUNDED PROJECT
Synthetic Matrix Biology: Designer matrices to program healthy and diseased myocardial morphogenesis
ERC Starting grant
2020-2025, 2M Eur
UNLOOC: Unlocking the data content of Organ-on-Chips
EC Chips Joint Undertaking and Italian Ministry of Enterprises
2024-2027, 1M Eur
LigHTS: All-Optical Engineering of Human Tissue Models for Ultra High-Throughput Drug Screening
MUR FARE
2022-2027, 400k Eur
highLight: A competence center for bio/nano-sustainability
Regione Lombardia
2021-2023, 250k Eur
Engineered in-vitro models of cardiometabolic diseases to screen RNA-based therapeutics
EU/MUR PNRR
2022-2025, 250k Eur
RESET. REsolving infections by modulating SEnescenT macrophages
MUR PRIN 2022
2023-2025, 125k Eur
MOST RECENT SPL PAPERS
MicroSplit : semantic unmixing of fluorescent microscopy data
Ashesh Ashesh, Federico Carrara, Igor Zubarev, Vera Galinova, Melisande Croft, Melissa Pezzotti, Daozheng Gong, Francesca Casagrande, Elisa Colombo, Stefania Giussani, Elena Restelli, Eugenia Cammarota, Juan Manuel Battagliotti, Nikolai Klena, Moises Di Sante, Raghabendra Adhikari, Daniel Feliciano, Gaia Pigino, Elena Taverna, Oliver Harschnitz, Nicola Maghelli, Norbert Scherer, Damian Edward Dalle Nogare , Joran Deschamps , Francesco Pasqualini, Florian Jug
PMID: 42086917
DOI: 10.1038/s41592-026-03082-1
Micro-comb 3D printing: rapid fabrication of tissue-guiding substrates using micro-embossed nozzles
Sarkhan Butdayev, Stefan Leone, Shayla Nikzad, Janko Kajtez, Katrine Bech Lauritzen, Moises Di Sante, Francesco S Pasqualini, Kirstine Calloe, Rodolphe Marie, Stephan S Keller, Anne Z Eriksen, Johan U Lind
PMID: 41985513
DOI: 10.1088/1758-5090/ae5fd9
Sandipan Chattaraj, Julius Zimmermann, Francesco Silvio Pasqualini
bioRxiv 2025.04.22.650069; doi: https://doi.org/10.1101/2025.04.22.650069
Bioimage analysis for multiplexed FUCCI acquisitions powered by deep learning
J. Zimmermann, M. Pezzotti, E. Torchia, A. Enrico, M. Di Sante,
F.S. Pasqualini
bioRxiv 2025.09.30.677886; doi: https://doi.org/10.1101/2025.09.30.677886
Melissa Pezzotti, Eloisa Torchia, Julius Zimmermann, Sara Rigolli, Alessandro Enrico, Moises Di Sante, Francesco S. Pasqualini
APL Bioeng. 10, 016114 (2026)
HIGHLY CITED FROM THE HARVARD DAYS
PREPRINT
Alessandro Enrico, Sara Rigolli, Julius Zimmermann, Melissa Pezzotti, Eloisa Torchia, Moises Di Sante, Ferdinando Auricchio, Francesco S. Pasqualini
bioRxiv 2025.10.23.683892;
doi: https://doi.org/10.1101/2025.10.23.683892
CALIPERS: Cell cycle-aware live imaging for phenotyping experiments and regeneration studies
Moises Di Sante, Melissa Pezzotti, Julius Zimmermann, Alessandro Enrico, Joran Deschamps, Elisa Balmas, Silvia Becca, Alessandro Reali, Alessandro Bertero, Florian Jug, Francesco S. Pasqualini
bioRxiv 2024.12.19.629259;
doi: https://doi.org/10.1101/2024.12.19.629259
Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing
Johan U Lind, Travis A Busbee, Alexander D Valentine, Francesco S Pasqualini, Hongyan Yuan, Moran Yadid, Sung-Jin Park, Arda Kotikian, Alexander P Nesmith, Patrick H Campbell, Joost J Vlassak, Jennifer A Lewis, Kevin K Parker
Nature materials 16 (3), 303-308 Paperpile PDF 907 citations | 2017
Phototactic guidance of a tissue-engineered soft-robotic ray
Sung-Jin Park, Mattia Gazzola, Kyung Soo Park, Shirley Park, Valentina Di Santo, Erin L Blevins, Johan U Lind, Patrick H Campbell, Stephanie Dauth, Andrew K Capulli, Francesco S Pasqualini, Seungkuk Ahn, Alexander Cho, Hongyan Yuan, Ben M Maoz, Ragu Vijaykumar, Jeong-Woo Choi, Karl Deisseroth, George V Lauder, L Mahadevan, Kevin Kit Parker
PMID: 27387948 PMCID: PMC552633 DOI: 10.1126/science.aaf4292
A novel computational model of the human ventricular action potential and Ca transient
Eleonora Grandi, Francesco S Pasqualini, Donald M Bers
PMID: 19835882 PMCID: PMC2813400 DOI: 10.1016/j.yjmcc.2009.09.019
A tissue-engineered scale model of the heart ventricle
Luke A MacQueen, Sean P Sheehy, Christophe O Chantre, John F Zimmerman, Francesco S Pasqualini, Xujie Liu, Josue A Goss, Patrick H Campbell, Grant M Gonzalez, Sung-Jin Park, Andrew K Capulli, John P Ferrier, T Fettah Kosar,
L Mahadevan, William T Pu, Kevin Kit Parker
PMID: 31015723 PMCID: PMC6774355 DOI: 10.1038/s41551-018-0271-5
Elena Cambria, Francesco S Pasqualini, Petra Wolint, Julia Günter,
Julia Steiger, Annina Bopp, Simon P Hoerstrup, Maximilian Y Emmert
PMID: 29302353 PMCID: PMC5677990 DOI: 10.1038/s41536-017-0024-1
JetValve: Rapid manufacturing of biohybrid scaffolds for biomimetic heart valve replacement
Andrew K Capulli, Maximillian Y Emmert, Francesco S Pasqualini, Debora Kehl, Etem Caliskan, Johan U Lind, Sean P Sheehy, Sung Jin Park, Seungkuk Ahn, Benedikt Weber, Josue A Goss, Simon P Hoerstrup, Kevin Kit Parker
PMID: 28445803 PMCID: PMC5526340 DOI: 10.1016/j.biomaterials.2017.04.033