Publications | Synthetic Physiolo 1

Welcome to our research publications section. Here, you will find a collection of our latest research papers and publications. Our team is dedicated to advancing the field of synthetic physiology through cutting-edge research and innovative discoveries.

Publication

29 / An Open-Science Computational Model of Organelle Acidification to Integrate Putative Mechanisms of Synaptic Vesicle Acidification and Filling.

Baraglia EC, Fattorini G, Chattaraj S, Pasqualini F, Conti F.

Neurochem Res. 2025 Jun 5;50(3):181. doi: 10.1007/s11064-025-04432-9.

PMID: 40471464 Free PMC article.

28 / Molecular Dynamics Simulation of Structural Assembly and Hydration of Hyaluronic Acid in Salt Aqueous Buffer.

Vasudevan S, Chattaraj S, Enrico A, Pasqualini FS.

Langmuir. 2025 Feb 18;41(6):3852-3864. doi: 10.1021/acs.langmuir.4c03966. Epub 2025 Feb 6.

PMID: 39913243 Free PMC article.

27 / Current progress toward isogeometric modeling of the heart biophysics.

Torre M, Morganti S, Pasqualini FS, Reali A.

Biophys Rev (Melville). 2023 Nov 13;4(4):041301. doi: 10.1063/5.0152690. eCollection 2023 Dec.

PMID: 38510845 Free PMC article. Review.

26 / When art and science collide.

Pasqualini F.

Biophys Rev (Melville). 2024 Mar 6;5(1):010401. doi: 10.1063/5.0203543. eCollection 2024 Mar.

PMID: 38505297 Free PMC article. No abstract available.

25 / SEM2: Introducing mechanics in cell and tissue modeling using coarse-grained homogeneous particle dynamics.

Chattaraj S, Torre M, Kalcher C, Stukowski A, Morganti S, Reali A, Pasqualini FS.

APL Bioeng. 2023 Dec 5;7(4):046118. doi: 10.1063/5.0166829. eCollection 2023 Dec.

PMID: 38075209 Free PMC article.

24 / A Pulsatile Flow System to Engineer Aneurysm and Atherosclerosis Mimetic Extracellular Matrix.

Hosseini V, Mallone A, Mirkhani N, Noir J, Salek M, Pasqualini FS, Schuerle S, Khademhosseini A, Hoerstrup SP, Vogel V.

Adv Sci (Weinh). 2020 Apr 30;7(12):2000173. doi: 10.1002/advs.202000173. eCollection 2020 Jun.

PMID: 32596117 Free PMC article.

23 / Insights Into the Pathogenesis of Catecholaminergic Polymorphic Ventricular Tachycardia From Engineered Human Heart Tissue.

Park SJ, Zhang D, Qi Y, Li Y, Lee KY, Bezzerides VJ, Yang P, Xia S, Kim SL, Liu X, Lu F, Pasqualini FS, Campbell PH, Geva J, Roberts AE, Kleber AG, Abrams DJ, Pu WT, Parker KK.

Circulation. 2019 Jul 30;140(5):390-404. doi: 10.1161/CIRCULATIONAHA.119.039711. Epub 2019 Jul 17.

PMID: 31311300 Free PMC article.

22 / A tissue-engineered scale model of the heart ventricle.

MacQueen LA, Sheehy SP, Chantre CO, Zimmerman JF, Pasqualini FS, Liu X, Goss JA, Campbell PH, Gonzalez GM, Park SJ, Capulli AK, Ferrier JP, Kosar TF, Mahadevan L, Pu WT, Parker KK.

Nat Biomed Eng. 2018 Dec;2(12):930-941. doi: 10.1038/s41551-018-0271-5. Epub 2018 Jul 23.

PMID: 31015723 Free PMC article.

21 / Traction force microscopy of engineered cardiac tissues.

Pasqualini FS, Agarwal A, O'Connor BB, Liu Q, Sheehy SP, Parker KK.

PLoS One. 2018 Mar 28;13(3):e0194706. doi: 10.1371/journal.pone.0194706. eCollection 2018.

PMID: 29590169 Free PMC article.

20 / Translational cardiac stem cell therapy: advancing from first-generation to next-generation cell types.

Cambria E, Pasqualini FS, Wolint P, Günter J, Steiger J, Bopp A, Hoerstrup SP, Emmert MY.

NPJ Regen Med. 2017 Jun 13;2:17. doi: 10.1038/s41536-017-0024-1. eCollection 2017.

PMID: 29302353 Free PMC article. Review.

19 / JetValve: Rapid manufacturing of biohybrid scaffolds for biomimetic heart valve replacement.

Capulli AK, Emmert MY, Pasqualini FS, Kehl D, Caliskan E, Lind JU, Sheehy SP, Park SJ, Ahn S, Weber B, Goss JA, Hoerstrup SP, Parker KK.

Biomaterials. 2017 Jul;133:229-241. doi: 10.1016/j.biomaterials.2017.04.033. Epub 2017 Apr 18.

PMID: 28445803 Free PMC article.

18 / Safety and efficacy of cardiopoietic stem cells in the treatment of post-infarction left-ventricular dysfunction - From cardioprotection to functional repair in a translational pig infarction model.

Emmert MY, Wolint P, Jakab A, Sheehy SP, Pasqualini FS, Nguyen TDL, Hilbe M, Seifert B, Weber B, Brokopp CE, Macejovska D, Caliskan E, von Eckardstein A, Schwartlander R, Vogel V, Falk V, Parker KK, Gyöngyösi M, Hoerstrup SP.

Biomaterials. 2017 Apr;122:48-62. doi: 10.1016/j.biomaterials.2016.11.029. Epub 2016 Nov 23.

PMID: 28107664

17 / Mechanotransduction and Metabolism in Cardiomyocyte Microdomains.

Pasqualini FS, Nesmith AP, Horton RE, Sheehy SP, Parker KK.

Biomed Res Int. 2016;2016:4081638. doi: 10.1155/2016/4081638. Epub 2016 Dec 4.

PMID: 28044126 Free PMC article. Review.

16 / Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing.

Lind JU, Busbee TA, Valentine AD, Pasqualini FS, Yuan H, Yadid M, Park SJ, Kotikian A, Nesmith AP, Campbell PH, Vlassak JJ, Lewis JA, Parker KK.

Nat Mater. 2017 Mar;16(3):303-308. doi: 10.1038/nmat4782. Epub 2016 Oct 24.

PMID: 27775708 Free PMC article.

15 / Heart Valve Replacements with Regenerative Capacity.

Dijkman PE, Fioretta ES, Frese L, Pasqualini FS, Hoerstrup SP.

Transfus Med Hemother. 2016 Jul;43(4):282-290. doi: 10.1159/000448181. Epub 2016 Jul 26.

PMID: 27721704 Free PMC article. Review.

14 / A human in vitro model of Duchenne muscular dystrophy muscle formation and contractility.

Nesmith AP, Wagner MA, Pasqualini FS, O'Connor BB, Pincus MJ, August PR, Parker KK.

J Cell Biol. 2016 Oct 10;215(1):47-56. doi: 10.1083/jcb.201603111. Epub 2016 Oct 3.

PMID: 27697929 Free PMC article.

13 / Phototactic guidance of a tissue-engineered soft-robotic ray.

Park SJ, Gazzola M, Park KS, Park S, Di Santo V, Blevins EL, Lind JU, Campbell PH, Dauth S, Capulli AK, Pasqualini FS, Ahn S, Cho A, Yuan H, Maoz BM, Vijaykumar R, Choi JW, Deisseroth K, Lauder GV, Mahadevan L, Parker KK.

Science. 2016 Jul 8;353(6295):158-62. doi: 10.1126/science.aaf4292.

PMID: 27387948 Free PMC article.

12 / Laminar ventricular myocardium on a microelectrode array-based chip.

Kujala VJ , Pasqualini FS , Goss JA , Nawroth JC , Parker KK .

J Mater Chem B. 2016 May 28;4(20):3534-3543. doi: 10.1039/c6tb00324a. Epub 2016 Apr 21.

PMID: 32263387

11 / Coupling primary and stem cell-derived cardiomyocytes in an in vitro model of cardiac cell therapy.

Aratyn-Schaus Y, Pasqualini FS, Yuan H, McCain ML, Ye GJ, Sheehy SP, Campbell PH, Parker KK.

J Cell Biol. 2016 Feb 15;212(4):389-97. doi: 10.1083/jcb.201508026. Epub 2016 Feb 8.

PMID: 26858266 Free PMC article.

10 / Angiotensin II Induced Cardiac Dysfunction on a Chip.

Horton RE, Yadid M, McCain ML, Sheehy SP, Pasqualini FS, Park SJ, Cho A, Campbell P, Parker KK.

PLoS One. 2016 Jan 25;11(1):e0146415. doi: 10.1371/journal.pone.0146415. eCollection 2016.

PMID: 26808388 Free PMC article.

9 / Late Na(+) current and protracted electrical recovery are critical determinants of the aging myopathy.

Signore S, Sorrentino A, Borghetti G, Cannata A, Meo M, Zhou Y, Kannappan R, Pasqualini F, O'Malley H, Sundman M, Tsigkas N, Zhang E, Arranto C, Mangiaracina C, Isobe K, Sena BF, Kim J, Goichberg P, Nahrendorf M, Isom LL, Leri A, Anversa P, Rota M.

Nat Commun. 2015 Nov 6;6:8803. doi: 10.1038/ncomms9803.

PMID: 26541940 Free PMC article.

8 / Structural phenotyping of stem cell-derived cardiomyocytes.

Nat Commun. 2015 Nov 6;6:8803. doi: 10.1038/ncomms9803.

PMID: 26541940 Free PMC article.

7 / Origin of cardiomyocytes in the adult heart.

Leri A, Rota M, Pasqualini FS, Goichberg P, Anversa P.

Circ Res. 2015 Jan 2;116(1):150-66. doi: 10.1161/CIRCRESAHA.116.303595.

PMID: 25552694 Free PMC article. Review.

6 / Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies.

Wang G, McCain ML, Yang L, He A, Pasqualini FS, Agarwal A, Yuan H, Jiang D, Zhang D, Zangi L, Geva J, Roberts AE, Ma Q, Ding J, Chen J, Wang DZ, Li K, Wang J, Wanders RJ, Kulik W, Vaz FM, Laflamme MA, Murry CE, Chien KR, Kelley RI, Church GM, Parker KK, Pu WT.

Nat Med. 2014 Jun;20(6):616-23. doi: 10.1038/nm.3545. Epub 2014 May 11.

PMID: 24813252 Free PMC article.

5 / Matrix elasticity regulates the optimal cardiac myocyte shape for contractility.

McCain ML, Yuan H, Pasqualini FS, Campbell PH, Parker KK.

Am J Physiol Heart Circ Physiol. 2014 Jun 1;306(11):H1525-39. doi: 10.1152/ajpheart.00799.2013. Epub 2014 Mar 28.

PMID: 24682394 Free PMC article.

4 / Quality metrics for stem cell-derived cardiac myocytes.

Sheehy SP, Pasqualini F, Grosberg A, Park SJ, Aratyn-Schaus Y, Parker KK.

Stem Cell Reports. 2014 Mar 6;2(3):282-94. doi: 10.1016/j.stemcr.2014.01.015. eCollection 2014 Mar 11.

PMID: 24672752 Free PMC article.

3 / The contractile strength of vascular smooth muscle myocytes is shape dependent.

Ye GJ, Aratyn-Schaus Y, Nesmith AP, Pasqualini FS, Alford PW, Parker KK.

Integr Biol (Camb). 2014 Feb;6(2):152-63. doi: 10.1039/c3ib40230d.

PMID: 24406783

2 / A novel computational model of the human ventricular action potential and Ca transient.

Grandi E, Pasqualini FS, Bers DM.

Mol Cell Cardiol. 2010 Jan;48(1):112-21. doi: 10.1016/j.yjmcc.2009.09.019. Epub 2009 Oct 14.

PMID: 19835882 Free PMC article.

1 / Theoretical investigation of action potential duration dependence on extracellular Ca2+ in human cardiomyocytes.

Grandi E, Pasqualini FS, Pes C, Corsi C, Zaza A, Severi S.

J Mol Cell Cardiol. 2009 Mar;46(3):332-42. doi: 10.1016/j.yjmcc.2008.12.002. Epub 2008 Dec 11.

PMID: 19121322