Insights into the Pathogenesis of Catecholaminergic Polymorphic Ventricular Tachycardia from Engineered Human Heart Tissue.

Circulation, 2019

Park SJ*, Zhang D*, Qi Y, Li Y, Lee KY, Bezzerides VJ, Yang P, Xia S, Kim SL, Liu X, Lu F, Pasqualini FS, Campbell PH, Geva J, Roberts AE, Kleber AG, Abrams DJ, Pu WT, Parker KK.

A tissue engineered model of the human ventricle.

Nature Biomedical Engineering, 2019

MacQueen LA, Sheehy SP, Chantre CO, Zimmerman JF, Pasqualini FS, Liu JX, Goss JA, Campbell PH, Gonzalez GM, Park SJ, Capulli AK, Ferrier JP, Kosar TF, Mahadevan L, Pu WT , Parker KK.

Traction force microscopy of engineered cardiac tissues.

Plos One, 2018

Pasqualini FS*, Agarwal A*, O'Connor BB, Liu Q, Sheehy SP, Parker KK.

Translational cardiac stem cell therapy: advancing from first-generation to next-generation cell types.

NPJ Regenerative Medicine, 2017

Cambria E, Pasqualini FS, Wolint P, Günter J, Steiger J, Bopp A, Hoerstrup SP, Emmert MY.

JetValve: Rapid manufacturing of biohybrid scaffolds for biomimetic heart valve replacement

Biomaterials, 2017

Capulli AK, Emmert MY, Pasqualini FS, Kehl D, Caliskan E, Lind JU, Sheehy SP,  Park SJ, Ahn S, Weber B, Goss JA, Hoerstrup SP, Parker KK.

Safety and efficacy of cardiopoietic stem cells in the treatment of post-infarction left-ventricular dysfunction - From cardioprotection to functional repair in a translational pig infarction model.

Biomaterials, 2017

Emmert MY, Wolint P, Jakab A, Sheehy SP, Pasqualini FS, Nguyen TD, Hilbe M, Seifert B, Weber B, Brokopp CE, Macejovska D, Caliskan E, von Eckardstein A, Schwartlander R, Vogel V, Falk V, Parker KK, Gyöngyösi M, Hoerstrup SP.

Mechanotransduction and Metabolism in Cardiomyocyte Microdomains.

Biomedical Research International, 2016

Pasqualini FS**, Nesmith AP, Horton RE, Sheehy SP, Parker KK.

** = corresponding author

Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing.

Nature Materials, 2017

Lind JU, Busbee TA, Valentine AD, Pasqualini FS, Yuan H, Yadid M, Park SJ, Kotikian A, Nesmith AP, Campbell PH, Vlassak JJ, Lewis JA, Parker KK.

Organs-on-a-chip: Quality assurance systems in regenerative medicine.

Clinical Pharmacology and Therapeutics, 2017

Pasqualini FS**, Emmert MY, Parker KK, Hoerstrup SP.

** = corresponding author

Heart Valve Replacements with Regenerative Capacity.

Transfusion Medicine and Hemotherapy, 2016

Dijkman PE, Fioretta ES, Frese L, Pasqualini FS, Hoerstrup SP.

A human in vitro model of Duchenne muscular dystrophy muscle formation and contractility.

Journal of Cell Biology, 2016

Nesmith AP, Wagner MA, Pasqualini FS, O'Connor BB, Pincus MJ, August PR, Parker KK.

Phototactic guidance of a tissue-engineered soft-robotic ray

Science, 2016

Park SJ, Gazzola M, Park KS, Park S, Di Santo V, Blevins EL, Lind JU, Campbell PH, Dauth S, Capulli AK, Pasqualini FS, Ahn S, Cho A, Yuan H, Maoz BM, Vijaykumar R, Choi JW, Deisseroth K, Lauder GV, Mahadevan L, Parker KK.

Laminar ventricular myocardium on a microelectrode array-based chip

Journal of Materials Chemistry B

Kujala VJ, Pasqualini FS, Goss JA, Nawroth JC, Parker KK.

Coupling primary and stem cell-derived cardiomyocytes in an in vitro model of cardiac cell therapy.

Journal of Cell Biology, 2016

Pasqualini FS*, Aratyn-Schaus Y*, Yuan H, McCain ML, Ye GJ, Sheehy SP, Campbell PH, Parker KK.

Angiotensin II Induced Cardiac Dysfunction on a Chip

Plos One, 2016

Horton RE, Yadid M, McCain ML, Sheehy SP, Pasqualini FS, Park SJ, Cho A, Campbell P, Parker KK.

Late Na(+) current and protracted electrical recovery are critical determinants of the aging myopathy

Nature Communications, 2015

Signore S*, Sorrentino A*, Borghetti G, Cannata A, Meo M, Zhou Y, Kannappan R, Pasqualini FS, O'Malley H, Sundman M, Tsigkas N, Zhang E, Arranto C, Mangiaracina C, Isobe K, Sena BF, Kim J, Goichberg P, Nahrendorf M, Isom LL, Leri A, Anversa P, Rota M.

Structural phenotyping of stem cell-derived cardiomyocytes.

Stem Cell Reports, 2015

Pasqualini FS, Sheehy SP, Agarwal A, Aratyn-Schaus Y, Parker KK.

Origin of cardiomyocytes in the adult heart.

Circulation Research, 2015

Leri A, Rota M, Pasqualini FS, Goichberg P, Anversa P.

Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies

Nature Medicine, 2014

Wang G*, McCain ML*, Yang L, He A, Pasqualini FS, Agarwal A, Yuan H, Jiang D, Zhang D, Zangi L, Geva J, Roberts AE, Ma Q, Ding J, Chen J, Wang DZ, Li K, Wang J, Wanders RJ, Kulik W, Vaz FM, Laflamme MA, Murry CE, Chien KR, Kelley RI, Church GM, Parker KK, Pu WT.

Matrix elasticity regulates the optimal cardiac myocyte shape for contractility.

AJP: Heart and Circulation Physiology 2014

McCain ML, Yuan H, Pasqualini FS, Campbell PH, Parker KK.

Quality metrics for stem cell-derived cardiac myocytes

Stem Cell Reports, 2014

Pasqualini FS*, Sheehy SP*, Grosberg A, Park SJ, Aratyn-Schaus Y, Parker KK

The Contractile Strength of Vascular Smooth Muscle Myocytes Is Shape Dependent.

Integr Biol (Camb), 2014

Ye GJ, Aratyn-Schaus Y, Nesmith AP, Pasqualini FS, Alford PW, Parker KK

A novel computational model of the human ventricular action potential and Ca transient.

Journal of Molecular and Cellular Cardiology, 2010

Grandi E, Pasqualini FS, Bers DM.

Theoretical investigation of action potential duration dependence on extracellular Ca2+ in human cardiomyocytes.

Journal of Molecular and Cellular Cardiology 2009

Grandi E, Pasqualini FS, Pes C, Corsi C, Zaza A, Severi S

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Data Fused Quality Index for Stem Cells. U.S. Utility 14/913,925 filed 02/23/16 Pub#2016-0203262

From the PI's time at Harvard.

Licensed to Emulate, Inc.

Engineering Physiologically Accurate Fibrous Organ Scaffolds. U.S. Prov. Appl. 62/586,520 - 11/15/2017

From the PI's time at Harvard

Computer-implemented method for designing an organ-on-chip device and computer-implemented method for analyzing the behavior of an organ-on-chip device. (IT) 10 2020 000010678

From University of Pavia



Synthetic Physiology Lab @ GitHub

Coming soon

COBRA: Cytoskeletal Organization and Benchmarking and Representation Assay

Software developed during the PI's time at Harvard, published in Stem Cell Reports and Nature Medicine papers. Mostly available at: (see paper #71)

Grandi-Pasqualini-Bers Model of Human Cardiac Myocytes

Software developed during the PI's time in Ancona, the GPB computational model of the human ventricular action potential and calcium transient was published in JMMC (2010). Available